Drug interactions
Ketorolac intranasal + Olmesartan
Severity: Moderate
Ketorolac intranasal and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac, even intranasally, is absorbed systemically and can reduce the antihypertensive effect of olmesartan. The combination raises the risk of acute kidney injury, especially in elderly or volume-depleted patients, and may cause hyperkalemia.
What this interaction means in plain words
Ketorolac intranasal and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis by ketorolac reduces renal perfusion and counteracts ARB effects, impairing glomerular filtration.
What to do
Monitor blood pressure, creatinine and potassium, and ensure adequate hydration. Limit ketorolac to the shortest course and avoid it in patients with renal impairment or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Ketorolac intranasal with Olmesartan?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac, even intranasally, is absorbed systemically and can reduce the antihypertensive effect of olmesartan. The combination raises the risk of acute kidney injury, especially in elderly or volume-depleted patients, and may cause hyperkalemia.
How serious is the interaction between Ketorolac intranasal and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, and ensure adequate hydration. Limit ketorolac to the shortest course and avoid it in patients with renal impairment or dehydration.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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