Drug interactions
Ketorolac intranasal + Propranolol
Severity: Moderate
Ketorolac intranasal and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac, even by the intranasal route, is systemically absorbed and can reduce the blood pressure lowering effect of propranolol with continued use. It may also impair renal function.
What this interaction means in plain words
Ketorolac intranasal and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and fluid retention and opposes antihypertensive effects.
What to do
Limit ketorolac to the labeled short duration and monitor blood pressure and renal function. Consider alternative analgesia in hypertensive patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Ketorolac intranasal with Propranolol?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac, even by the intranasal route, is systemically absorbed and can reduce the blood pressure lowering effect of propranolol with continued use. It may also impair renal function.
How serious is the interaction between Ketorolac intranasal and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the labeled short duration and monitor blood pressure and renal function. Consider alternative analgesia in hypertensive patients.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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