Drug interactions
Ketorolac intranasal + Rivastigmine
Severity: Moderate
Ketorolac intranasal and Rivastigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is a potent NSAID with notable GI toxicity even when given intranasally, and cholinesterase inhibitors increase gastric acid secretion. Combined use may raise the risk of ulceration and bleeding, particularly in older patients.
What this interaction means in plain words
Ketorolac intranasal and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GI toxicity from cholinergic stimulation of acid secretion and NSAID inhibition of protective prostaglandins.
What to do
Limit ketorolac to the shortest course and monitor for dyspepsia, melena or GI bleeding; consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivastigmine
Frequently asked questions
Can I take Ketorolac intranasal with Rivastigmine?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is a potent NSAID with notable GI toxicity even when given intranasally, and cholinesterase inhibitors increase gastric acid secretion. Combined use may raise the risk of ulceration and bleeding, particularly in older patients.
How serious is the interaction between Ketorolac intranasal and Rivastigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest course and monitor for dyspepsia, melena or GI bleeding; consider gastroprotection in high-risk patients.
What other medicines interact with Rivastigmine?
MediHelp also lists interactions of Rivastigmine with, for example, Donepezil, Galantamine, Memantine-donepezil. The full list is on the Rivastigmine page.
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