Drug interactions
Lamivudine + Tenofovir disoproxil
Severity: Minor
Lamivudine and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
These drugs are commonly used together in HIV and HBV regimens without a meaningful interaction. IRIS is a general consequence of immune recovery on antiretroviral therapy and not specific to this pair. Both are renally cleared but do not interact adversely at standard doses.
What this interaction means in plain words
Lamivudine and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No clinically relevant pharmacokinetic or pharmacodynamic interaction is established.
What to do
No adjustment is needed beyond renal dose adjustment as indicated. Monitor patients with advanced immunosuppression for IRIS after starting therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lamivudine
Frequently asked questions
Can I take Lamivudine with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Lamivudine and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. These drugs are commonly used together in HIV and HBV regimens without a meaningful interaction. IRIS is a general consequence of immune recovery on antiretroviral therapy and not specific to this pair. Both are renally cleared but do not interact adversely at standard doses.
How serious is the interaction between Lamivudine and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed beyond renal dose adjustment as indicated. Monitor patients with advanced immunosuppression for IRIS after starting therapy.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Lamivudine page.
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