Drug interactions
Lamotrigine + Levonorgestrel intrauterine
Severity: Minor
Lamotrigine and Levonorgestrel intrauterine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levonorgestrel released from an intrauterine system produces low systemic exposure and, unlike estrogen-containing contraceptives, is not known to meaningfully reduce lamotrigine levels. A clinically important interaction is unlikely.
What this interaction means in plain words
Lamotrigine and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lamotrigine glucuronidation induction is mainly an estrogen effect, and progestin-only local delivery has minimal systemic impact.
What to do
No routine lamotrigine dose adjustment is needed. Monitor seizure control as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lamotrigine and Levonorgestrel intrauterine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Lamotrigine
Frequently asked questions
Can I take Lamotrigine with Levonorgestrel intrauterine?
MediHelp rates the interaction as minor. Lamotrigine and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levonorgestrel released from an intrauterine system produces low systemic exposure and, unlike estrogen-containing contraceptives, is not known to meaningfully reduce lamotrigine levels. A clinically important interaction is unlikely.
How serious is the interaction between Lamotrigine and Levonorgestrel intrauterine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine lamotrigine dose adjustment is needed. Monitor seizure control as usual.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
