Drug interactions
Lamotrigine + Mestranol
Severity: Moderate
Lamotrigine and Mestranol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mestranol is an estrogen converted to ethinylestradiol, which lowers lamotrigine concentrations and may reduce seizure control. Levels can rebound when the estrogen is withdrawn.
What this interaction means in plain words
Lamotrigine and Mestranol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estrogen induces UDP-glucuronosyltransferase, increasing lamotrigine glucuronidation.
What to do
Monitor seizure control and adjust the lamotrigine dose when starting or stopping the estrogen. Consider checking lamotrigine levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Frequently asked questions
Can I take Lamotrigine with Mestranol?
MediHelp rates the interaction as moderate. Lamotrigine and Mestranol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mestranol is an estrogen converted to ethinylestradiol, which lowers lamotrigine concentrations and may reduce seizure control. Levels can rebound when the estrogen is withdrawn.
How serious is the interaction between Lamotrigine and Mestranol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and adjust the lamotrigine dose when starting or stopping the estrogen. Consider checking lamotrigine levels.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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