Drug interactions
Lamotrigine + Norelgestromin
Severity: Moderate
Lamotrigine and Norelgestromin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norelgestromin is used with ethinylestradiol in the contraceptive patch, and the estrogen component lowers lamotrigine concentrations. This may reduce seizure control.
What this interaction means in plain words
Lamotrigine and Norelgestromin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ethinylestradiol induces lamotrigine glucuronidation via UDP-glucuronosyltransferase.
What to do
Monitor seizure control and adjust the lamotrigine dose when the patch is started or stopped. Watch for toxicity if the patch is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Frequently asked questions
Can I take Lamotrigine with Norelgestromin?
MediHelp rates the interaction as moderate. Lamotrigine and Norelgestromin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norelgestromin is used with ethinylestradiol in the contraceptive patch, and the estrogen component lowers lamotrigine concentrations. This may reduce seizure control.
How serious is the interaction between Lamotrigine and Norelgestromin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and adjust the lamotrigine dose when the patch is started or stopped. Watch for toxicity if the patch is discontinued.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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