Drug interactions
Lamotrigine + Norethindrone
Severity: Moderate
Lamotrigine and Norethindrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined contraceptives containing norethindrone and estrogen lower lamotrigine levels, but progestin-only norethindrone has little effect. The relevance depends on the estrogen content of the product.
What this interaction means in plain words
Lamotrigine and Norethindrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estrogen-mediated induction of lamotrigine glucuronidation; progestin alone has minimal effect.
What to do
If the product contains ethinylestradiol, monitor seizure control and adjust lamotrigine when starting or stopping it. No adjustment is typically needed for progestin-only products.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Frequently asked questions
Can I take Lamotrigine with Norethindrone?
MediHelp rates the interaction as moderate. Lamotrigine and Norethindrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined contraceptives containing norethindrone and estrogen lower lamotrigine levels, but progestin-only norethindrone has little effect. The relevance depends on the estrogen content of the product.
How serious is the interaction between Lamotrigine and Norethindrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the product contains ethinylestradiol, monitor seizure control and adjust lamotrigine when starting or stopping it. No adjustment is typically needed for progestin-only products.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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