Drug interactions
Lamotrigine + Norgestimate
Severity: Moderate
Lamotrigine and Norgestimate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norgestimate is usually combined with ethinylestradiol, and such combinations lower lamotrigine concentrations, which may reduce seizure control. Levels may rise when hormone-free days occur.
What this interaction means in plain words
Lamotrigine and Norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ethinylestradiol induces lamotrigine glucuronidation.
What to do
Monitor seizure control and adjust the lamotrigine dose when starting or stopping the contraceptive. Watch for toxicity in the placebo week.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Frequently asked questions
Can I take Lamotrigine with Norgestimate?
MediHelp rates the interaction as moderate. Lamotrigine and Norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norgestimate is usually combined with ethinylestradiol, and such combinations lower lamotrigine concentrations, which may reduce seizure control. Levels may rise when hormone-free days occur.
How serious is the interaction between Lamotrigine and Norgestimate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and adjust the lamotrigine dose when starting or stopping the contraceptive. Watch for toxicity in the placebo week.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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