Drug interactions
Lansoprazole + Ledipasvir / sofosbuvir
Severity: Moderate
Lansoprazole and Ledipasvir / sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir dissolves poorly at higher pH, so acid suppression can reduce its absorption and risk reduced hepatitis C cure rates. The effect is dose and timing dependent.
What this interaction means in plain words
Lansoprazole and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Raised gastric pH decreases ledipasvir solubility and absorption.
What to do
Give the PPI simultaneously with ledipasvir/sofosbuvir under fasted conditions at a dose no higher than omeprazole 20 mg equivalent. Avoid higher PPI doses where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Ledipasvir / sofosbuvir?
MediHelp rates the interaction as moderate. Lansoprazole and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir dissolves poorly at higher pH, so acid suppression can reduce its absorption and risk reduced hepatitis C cure rates. The effect is dose and timing dependent.
How serious is the interaction between Lansoprazole and Ledipasvir / sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the PPI simultaneously with ledipasvir/sofosbuvir under fasted conditions at a dose no higher than omeprazole 20 mg equivalent. Avoid higher PPI doses where possible.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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