Drug interactions
Lansoprazole + Lumacaftor / ivacaftor
Severity: Minor
Lansoprazole and Lumacaftor / ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor induces CYP3A and CYP2C19, which may lower lansoprazole exposure and weaken acid suppression. Ivacaftor has some inhibitory potential, so the net effect varies.
What this interaction means in plain words
Lansoprazole and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lumacaftor induces CYP3A4 and CYP2C19 and ivacaftor may inhibit them, altering lansoprazole clearance.
What to do
Monitor reflux symptom control and increase lansoprazole dose if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Lumacaftor / ivacaftor?
MediHelp rates the interaction as minor. Lansoprazole and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumacaftor induces CYP3A and CYP2C19, which may lower lansoprazole exposure and weaken acid suppression. Ivacaftor has some inhibitory potential, so the net effect varies.
How serious is the interaction between Lansoprazole and Lumacaftor / ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor reflux symptom control and increase lansoprazole dose if the response is inadequate.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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