Drug interactions
Lansoprazole + Mycophenolate
Severity: Moderate
Lansoprazole and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
PPIs can reduce mycophenolate mofetil absorption, lowering mycophenolic acid exposure, which may raise the risk of rejection. The enteric-coated sodium formulation appears less affected.
What this interaction means in plain words
Lansoprazole and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Higher gastric pH reduces dissolution and absorption of mycophenolate mofetil.
What to do
Monitor for graft function and consider mycophenolic acid exposure monitoring. Consider switching to enteric-coated mycophenolate sodium or reassess the need for the PPI.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Mycophenolate?
MediHelp rates the interaction as moderate. Lansoprazole and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. PPIs can reduce mycophenolate mofetil absorption, lowering mycophenolic acid exposure, which may raise the risk of rejection. The enteric-coated sodium formulation appears less affected.
How serious is the interaction between Lansoprazole and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for graft function and consider mycophenolic acid exposure monitoring. Consider switching to enteric-coated mycophenolate sodium or reassess the need for the PPI.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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