Drug interactions
Lansoprazole + Nafcillin
Severity: Minor
Lansoprazole and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is an inducer of CYP3A4 and may lower lansoprazole exposure. The effect on acid suppression is probably small and short courses of nafcillin limit the impact.
What this interaction means in plain words
Lansoprazole and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 increases the metabolism of lansoprazole.
What to do
No routine adjustment is needed; reassess acid-related symptoms if the combination is prolonged and increase the PPI dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Nafcillin?
MediHelp rates the interaction as minor. Lansoprazole and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin is an inducer of CYP3A4 and may lower lansoprazole exposure. The effect on acid suppression is probably small and short courses of nafcillin limit the impact.
How serious is the interaction between Lansoprazole and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess acid-related symptoms if the combination is prolonged and increase the PPI dose if control is lost.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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