Drug interactions
Lansoprazole + Pentobarbital
Severity: Minor
Lansoprazole and Pentobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces hepatic enzymes and can reduce lansoprazole concentrations, possibly weakening acid suppression. The clinical significance is likely small for short-term use.
What this interaction means in plain words
Lansoprazole and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP2C19 and CYP3A4 accelerates lansoprazole metabolism.
What to do
Monitor for loss of symptom control with prolonged co-use and consider raising the lansoprazole dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lansoprazole and Pentobarbital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Pentobarbital?
MediHelp rates the interaction as minor. Lansoprazole and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentobarbital induces hepatic enzymes and can reduce lansoprazole concentrations, possibly weakening acid suppression. The clinical significance is likely small for short-term use.
How serious is the interaction between Lansoprazole and Pentobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control with prolonged co-use and consider raising the lansoprazole dose if needed.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
