Drug interactions
Lansoprazole + Ponatinib
Severity: Minor
Lansoprazole and Ponatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib has pH-dependent solubility, and lansoprazole could lower its exposure. In studies, lansoprazole did not produce a clinically meaningful reduction in ponatinib exposure, so the effect is likely small.
What this interaction means in plain words
Lansoprazole and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Ponatinib belongs to Oncology.
Why it happens
Higher gastric pH may reduce ponatinib dissolution, though the observed effect is small.
What to do
No dose change is required; monitor response to ponatinib as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Ponatinib
Frequently asked questions
Can I take Lansoprazole with Ponatinib?
MediHelp rates the interaction as minor. Lansoprazole and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ponatinib has pH-dependent solubility, and lansoprazole could lower its exposure. In studies, lansoprazole did not produce a clinically meaningful reduction in ponatinib exposure, so the effect is likely small.
How serious is the interaction between Lansoprazole and Ponatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor response to ponatinib as usual.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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