Drug interactions
Lansoprazole + Rifampin
Severity: Moderate
Lansoprazole and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces CYP2C19 and CYP3A4, substantially reducing lansoprazole exposure. Acid suppression may be inadequate, with reduced ulcer healing or reflux control.
What this interaction means in plain words
Lansoprazole and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induction of CYP2C19 and CYP3A4 increases lansoprazole metabolism.
What to do
Monitor symptom control and consider a higher lansoprazole dose or an H2 blocker if acid suppression is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Rifampin?
MediHelp rates the interaction as moderate. Lansoprazole and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces CYP2C19 and CYP3A4, substantially reducing lansoprazole exposure. Acid suppression may be inadequate, with reduced ulcer healing or reflux control.
How serious is the interaction between Lansoprazole and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and consider a higher lansoprazole dose or an H2 blocker if acid suppression is lost.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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