Drug interactions
Lansoprazole + Saquinavir
Severity: Moderate
Lansoprazole and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lansoprazole can modestly raise saquinavir exposure, and saquinavir is associated with dose-related QT and PR prolongation. The increase may add to cardiac conduction risk, particularly in patients with other risk factors.
What this interaction means in plain words
Lansoprazole and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Proton pump inhibitors appear to raise saquinavir concentrations, probably by affecting its absorption or first-pass metabolism, but the exact mechanism is not established.
What to do
Obtain a baseline ECG and monitor QT interval and saquinavir toxicity when the combination is used. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Saquinavir?
MediHelp rates the interaction as moderate. Lansoprazole and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lansoprazole can modestly raise saquinavir exposure, and saquinavir is associated with dose-related QT and PR prolongation. The increase may add to cardiac conduction risk, particularly in patients with other risk factors.
How serious is the interaction between Lansoprazole and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QT interval and saquinavir toxicity when the combination is used. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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