Drug interactions
Lansoprazole + Secretin
Severity: Moderate
Lansoprazole and Secretin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
PPIs raise serum gastrin and can cause an exaggerated gastrin response to the secretin stimulation test, giving a false-positive result for gastrinoma. This could lead to unnecessary investigation or treatment.
What this interaction means in plain words
Lansoprazole and Secretin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chronic acid suppression causes hypergastrinaemia that alters the gastrin response measured in secretin stimulation testing.
What to do
Where clinically safe, stop lansoprazole for the period recommended in labeling before testing, with an H2 blocker bridge if needed, and interpret results cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Secretin?
MediHelp rates the interaction as moderate. Lansoprazole and Secretin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. PPIs raise serum gastrin and can cause an exaggerated gastrin response to the secretin stimulation test, giving a false-positive result for gastrinoma. This could lead to unnecessary investigation or treatment.
How serious is the interaction between Lansoprazole and Secretin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where clinically safe, stop lansoprazole for the period recommended in labeling before testing, with an H2 blocker bridge if needed, and interpret results cautiously.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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