Drug interactions
Lansoprazole + Sofosbuvir / velpatasvir
Severity: Major
Lansoprazole and Sofosbuvir / velpatasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir solubility falls sharply as gastric pH rises, so lansoprazole can reduce velpatasvir exposure. This may lead to hepatitis C treatment failure.
What this interaction means in plain words
Lansoprazole and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Higher gastric pH reduces velpatasvir solubility and absorption.
What to do
Avoid PPIs with sofosbuvir/velpatasvir. If unavoidable, follow labeling by giving it with food 4 hours before omeprazole 20 mg, or switch to an alternative HCV regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as major. Lansoprazole and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Velpatasvir solubility falls sharply as gastric pH rises, so lansoprazole can reduce velpatasvir exposure. This may lead to hepatitis C treatment failure.
How serious is the interaction between Lansoprazole and Sofosbuvir / velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with sofosbuvir/velpatasvir. If unavoidable, follow labeling by giving it with food 4 hours before omeprazole 20 mg, or switch to an alternative HCV regimen.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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