Drug interactions
Lansoprazole + Theophylline
Severity: Minor
Lansoprazole and Theophylline: minor interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lansoprazole has been reported to slightly increase theophylline clearance rather than decrease it, with minimal clinical effect. Labeling suggests monitoring in some patients, but the effect is small.
What this interaction means in plain words
Lansoprazole and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Theophylline belongs to Respiratory.
Why it happens
Possible weak induction of CYP1A2-mediated theophylline metabolism; the mechanism is not firmly established.
What to do
Monitor theophylline levels when starting or stopping lansoprazole in patients with levels near the upper therapeutic range, and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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References
- Lansoprazole - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Theophylline?
MediHelp rates the interaction as minor. Lansoprazole and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lansoprazole has been reported to slightly increase theophylline clearance rather than decrease it, with minimal clinical effect. Labeling suggests monitoring in some patients, but the effect is small.
How serious is the interaction between Lansoprazole and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline levels when starting or stopping lansoprazole in patients with levels near the upper therapeutic range, and adjust the dose if needed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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