Drug interactions
Ledipasvir / sofosbuvir + Tenofovir disoproxil
Severity: Moderate
Ledipasvir / sofosbuvir and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir increases tenofovir exposure, with a larger effect when tenofovir is given with a ritonavir- or cobicistat-boosted regimen. Higher tenofovir levels raise the risk of renal toxicity and bone effects.
What this interaction means in plain words
Ledipasvir / sofosbuvir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ledipasvir inhibits intestinal P-glycoprotein and BCRP, increasing tenofovir absorption.
What to do
Monitor renal function, including creatinine clearance and phosphate, regularly; avoid with boosted regimens unless benefit outweighs risk, and avoid in patients with eGFR below 30 mL/min.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Ledipasvir / sofosbuvir with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Ledipasvir / sofosbuvir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir increases tenofovir exposure, with a larger effect when tenofovir is given with a ritonavir- or cobicistat-boosted regimen. Higher tenofovir levels raise the risk of renal toxicity and bone effects.
How serious is the interaction between Ledipasvir / sofosbuvir and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, including creatinine clearance and phosphate, regularly; avoid with boosted regimens unless benefit outweighs risk, and avoid in patients with eGFR below 30 mL/min.
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