Drug interactions
Lefamulin + Pimozide
Severity: Contraindicated
Lefamulin and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin inhibits CYP3A4 and itself can prolong the QT interval, so it may raise pimozide levels while adding to QT effects. This raises the risk of torsades de pointes.
What this interaction means in plain words
Lefamulin and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lefamulin belongs to Anti Bacterial; Pimozide belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reduces pimozide clearance, with additive QT prolongation.
What to do
Avoid the combination. Use an alternative antibiotic for the infection being treated.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
- Amisulpride + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Pimozide?
MediHelp rates the interaction as contraindicated. Lefamulin and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lefamulin inhibits CYP3A4 and itself can prolong the QT interval, so it may raise pimozide levels while adding to QT effects. This raises the risk of torsades de pointes.
How serious is the interaction between Lefamulin and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use an alternative antibiotic for the infection being treated.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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