Drug interactions
Levonorgestrel intrauterine + Topiramate
Severity: Minor
Levonorgestrel intrauterine and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intrauterine system acts mainly locally with low systemic levels, so the contraceptive effect is not expected to be meaningfully reduced by topiramate.
What this interaction means in plain words
Levonorgestrel intrauterine and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Topiramate may induce CYP3A4, but the local uterine action of the device makes systemic changes largely irrelevant.
What to do
No additional contraception is generally needed; the intrauterine system remains a recommended method for women taking topiramate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topiramate
Frequently asked questions
Can I take Levonorgestrel intrauterine with Topiramate?
MediHelp rates the interaction as minor. Levonorgestrel intrauterine and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The intrauterine system acts mainly locally with low systemic levels, so the contraceptive effect is not expected to be meaningfully reduced by topiramate.
How serious is the interaction between Levonorgestrel intrauterine and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraception is generally needed; the intrauterine system remains a recommended method for women taking topiramate.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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