Drug interactions
Levorphanol + Pimozide
Severity: Moderate
Levorphanol and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause excessive sedation, impaired psychomotor performance and respiratory depression. The risk is greatest in the elderly, with higher opioid doses, or when other sedatives are present.
What this interaction means in plain words
Levorphanol and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of an opioid agonist and a sedating antipsychotic.
What to do
Start levorphanol at the lowest effective dose and titrate slowly while monitoring sedation and respiratory rate. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Levorphanol with Pimozide?
MediHelp rates the interaction as moderate. Levorphanol and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause excessive sedation, impaired psychomotor performance and respiratory depression. The risk is greatest in the elderly, with higher opioid doses, or when other sedatives are present.
How serious is the interaction between Levorphanol and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start levorphanol at the lowest effective dose and titrate slowly while monitoring sedation and respiratory rate. Counsel patients to avoid driving and alcohol.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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