Drug interactions
Levosalbutamol + Methyclothiazide
Severity: Moderate
Levosalbutamol and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics waste potassium, and beta-2 agonists drive potassium into cells. Together they can cause clinically significant hypokalemia, which may provoke arrhythmias, especially with high-dose or repeated levosalbutamol.
What this interaction means in plain words
Levosalbutamol and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive lowering of serum potassium through renal loss (thiazide) and intracellular shift (beta-2 agonist).
What to do
Monitor serum potassium, particularly during acute asthma or COPD exacerbations or with high-dose nebulized therapy. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Frequently asked questions
Can I take Levosalbutamol with Methyclothiazide?
MediHelp rates the interaction as moderate. Levosalbutamol and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics waste potassium, and beta-2 agonists drive potassium into cells. Together they can cause clinically significant hypokalemia, which may provoke arrhythmias, especially with high-dose or repeated levosalbutamol.
How serious is the interaction between Levosalbutamol and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly during acute asthma or COPD exacerbations or with high-dose nebulized therapy. Replace potassium as needed.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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