Drug interactions
Levosalbutamol + Norepinephrine
Severity: Moderate
Levosalbutamol and Norepinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine is a potent vasopressor and levosalbutamol is a beta-2 agonist, so together they can add to tachycardia, arrhythmia risk and blood pressure changes. Beta-agonists may also lower serum potassium, which adds to arrhythmic risk in critically ill patients.
What this interaction means in plain words
Levosalbutamol and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic receptor stimulation and beta-2 mediated intracellular potassium shift.
What to do
Monitor ECG, blood pressure and serum potassium during concurrent use, and titrate norepinephrine to hemodynamic targets. Limit levosalbutamol dosing frequency where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Frequently asked questions
Can I take Levosalbutamol with Norepinephrine?
MediHelp rates the interaction as moderate. Levosalbutamol and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norepinephrine is a potent vasopressor and levosalbutamol is a beta-2 agonist, so together they can add to tachycardia, arrhythmia risk and blood pressure changes. Beta-agonists may also lower serum potassium, which adds to arrhythmic risk in critically ill patients.
How serious is the interaction between Levosalbutamol and Norepinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, blood pressure and serum potassium during concurrent use, and titrate norepinephrine to hemodynamic targets. Limit levosalbutamol dosing frequency where feasible.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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