Drug interactions
Levosalbutamol + Olodaterol inhaled
Severity: Moderate
Levosalbutamol and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are beta-2 agonists, so combining a short-acting agent with the long-acting olodaterol duplicates receptor stimulation. This can increase tachycardia, tremor, palpitations and hypokalemia, although as-needed levosalbutamol for breakthrough symptoms is commonly accepted.
What this interaction means in plain words
Levosalbutamol and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-2 adrenergic receptor stimulation.
What to do
Limit levosalbutamol to rescue use and review the patient if frequent doses are needed. Monitor heart rate and potassium in patients with cardiac disease or at high risk of hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Frequently asked questions
Can I take Levosalbutamol with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Levosalbutamol and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are beta-2 agonists, so combining a short-acting agent with the long-acting olodaterol duplicates receptor stimulation. This can increase tachycardia, tremor, palpitations and hypokalemia, although as-needed levosalbutamol for breakthrough symptoms is commonly accepted.
How serious is the interaction between Levosalbutamol and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit levosalbutamol to rescue use and review the patient if frequent doses are needed. Monitor heart rate and potassium in patients with cardiac disease or at high risk of hypokalemia.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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