Drug interactions
Levosalbutamol + Phenoxybenzamine
Severity: Moderate
Levosalbutamol and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine blocks alpha-adrenergic receptors, while levosalbutamol causes beta-2 mediated vasodilation and reflex tachycardia. Together they may cause an exaggerated fall in blood pressure with a compensatory rise in heart rate.
What this interaction means in plain words
Levosalbutamol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Unopposed beta-2 vasodilation combined with alpha-adrenergic blockade produces additive hypotension and reflex tachycardia.
What to do
Monitor blood pressure and heart rate when starting or increasing either drug, and advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Frequently asked questions
Can I take Levosalbutamol with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Levosalbutamol and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine blocks alpha-adrenergic receptors, while levosalbutamol causes beta-2 mediated vasodilation and reflex tachycardia. Together they may cause an exaggerated fall in blood pressure with a compensatory rise in heart rate.
How serious is the interaction between Levosalbutamol and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or increasing either drug, and advise patients to rise slowly.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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