Drug interactions
Lily of the valley + Propranolol
Severity: Major
Lily of the valley and Propranolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lily of the valley contains cardiac glycosides, which slow AV conduction and can cause bradycardia and arrhythmia. Propranolol adds negative chronotropic and dromotropic effects, raising the risk of heart block.
What this interaction means in plain words
Lily of the valley and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive suppression of AV nodal conduction by glycoside effect and beta-blockade.
What to do
Avoid the herbal product. If exposure occurs, monitor ECG and heart rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Lily of the valley with Propranolol?
MediHelp rates the interaction as major. Lily of the valley and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lily of the valley contains cardiac glycosides, which slow AV conduction and can cause bradycardia and arrhythmia. Propranolol adds negative chronotropic and dromotropic effects, raising the risk of heart block.
How serious is the interaction between Lily of the valley and Propranolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the herbal product. If exposure occurs, monitor ECG and heart rate.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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