Drug interactions
Liotrix + Rabeprazole
Severity: Moderate
Liotrix and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liotrix contains levothyroxine and liothyronine, and levothyroxine absorption depends partly on gastric acidity. Proton pump inhibitors may raise TSH in some patients, although evidence is mixed.
What this interaction means in plain words
Liotrix and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Raised gastric pH can reduce dissolution and absorption of oral thyroid hormone.
What to do
Monitor TSH about 6 to 8 weeks after starting or stopping rabeprazole and titrate the thyroid hormone dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Liotrix with Rabeprazole?
MediHelp rates the interaction as moderate. Liotrix and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liotrix contains levothyroxine and liothyronine, and levothyroxine absorption depends partly on gastric acidity. Proton pump inhibitors may raise TSH in some patients, although evidence is mixed.
How serious is the interaction between Liotrix and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor TSH about 6 to 8 weeks after starting or stopping rabeprazole and titrate the thyroid hormone dose accordingly.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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