Drug interactions
Lisinopril + Sacubitril / valsartan
Severity: Contraindicated
Lisinopril and Sacubitril / valsartan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an ACE inhibitor with sacubitril/valsartan raises the risk of angioedema because both reduce bradykinin breakdown. The combination is contraindicated in labeling.
What this interaction means in plain words
Lisinopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Neprilysin inhibition plus ACE inhibition both impair bradykinin degradation, increasing angioedema risk.
What to do
Never co-administer; allow a 36-hour washout after stopping the ACE inhibitor before starting sacubitril/valsartan, and likewise when switching back.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Lisinopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an ACE inhibitor with sacubitril/valsartan raises the risk of angioedema because both reduce bradykinin breakdown. The combination is contraindicated in labeling.
How serious is the interaction between Lisinopril and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never co-administer; allow a 36-hour washout after stopping the ACE inhibitor before starting sacubitril/valsartan, and likewise when switching back.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril-valsartan. The full list is on the Lisinopril page.
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