Drug interactions
Lisocabtagene maraleucel + Mercaptopurine
Severity: Major
Lisocabtagene maraleucel and Mercaptopurine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mercaptopurine is a cytotoxic immunosuppressant and may impair the function of CAR-T cells. It also adds to the infection risk that follows CAR-T therapy.
What this interaction means in plain words
Lisocabtagene maraleucel and Mercaptopurine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lisocabtagene maraleucel belongs to Oncology; Mercaptopurine belongs to Oncology.
Why it happens
Additive immunosuppression and antimetabolite effects on lymphocytes may reduce CAR-T expansion and persistence.
What to do
Avoid mercaptopurine around leukapheresis and CAR-T infusion unless essential, and follow the product labeling and specialist guidance. Monitor closely for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Other interactions of Lisocabtagene maraleucel
Frequently asked questions
Can I take Lisocabtagene maraleucel with Mercaptopurine?
MediHelp rates the interaction as major. Lisocabtagene maraleucel and Mercaptopurine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mercaptopurine is a cytotoxic immunosuppressant and may impair the function of CAR-T cells. It also adds to the infection risk that follows CAR-T therapy.
How serious is the interaction between Lisocabtagene maraleucel and Mercaptopurine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid mercaptopurine around leukapheresis and CAR-T infusion unless essential, and follow the product labeling and specialist guidance. Monitor closely for infection.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
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