Drug interactions
Lisocabtagene maraleucel + Methotrexate
Severity: Major
Lisocabtagene maraleucel and Methotrexate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisocabtagene maraleucel causes cytopenias and immune deficiency, and methotrexate adds immunosuppression and myelosuppression. The combination raises infection risk and immunosuppressants may reduce CAR-T cell expansion and efficacy.
What this interaction means in plain words
Lisocabtagene maraleucel and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lisocabtagene maraleucel belongs to Oncology; Methotrexate belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression, with possible impairment of CAR-T cell expansion and persistence.
What to do
Avoid methotrexate around CAR-T infusion and during recovery unless clearly necessary. If it is used, monitor blood counts and infections closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Lisocabtagene maraleucel
Frequently asked questions
Can I take Lisocabtagene maraleucel with Methotrexate?
MediHelp rates the interaction as major. Lisocabtagene maraleucel and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lisocabtagene maraleucel causes cytopenias and immune deficiency, and methotrexate adds immunosuppression and myelosuppression. The combination raises infection risk and immunosuppressants may reduce CAR-T cell expansion and efficacy.
How serious is the interaction between Lisocabtagene maraleucel and Methotrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid methotrexate around CAR-T infusion and during recovery unless clearly necessary. If it is used, monitor blood counts and infections closely.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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