Drug interactions
Lisocabtagene maraleucel + Tofacitinib
Severity: Major
Lisocabtagene maraleucel and Tofacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tofacitinib may impair CAR-T cell expansion and function and adds to infection risk after CAR-T therapy.
What this interaction means in plain words
Lisocabtagene maraleucel and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lisocabtagene maraleucel belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
JAK inhibition suppresses T-cell signaling, causing additive immunosuppression and possible interference with CAR-T activity.
What to do
Avoid tofacitinib around leukapheresis and infusion unless essential, following the treating team's protocol. Monitor for infection if it is used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Lisocabtagene maraleucel
Frequently asked questions
Can I take Lisocabtagene maraleucel with Tofacitinib?
MediHelp rates the interaction as major. Lisocabtagene maraleucel and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tofacitinib may impair CAR-T cell expansion and function and adds to infection risk after CAR-T therapy.
How serious is the interaction between Lisocabtagene maraleucel and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid tofacitinib around leukapheresis and infusion unless essential, following the treating team's protocol. Monitor for infection if it is used.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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