Drug interactions
Lithium + Loxapine inhaled
Severity: Moderate
Lithium and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium combined with antipsychotics has been associated with neurotoxicity, extrapyramidal effects and, rarely, neuroleptic malignant syndrome. Inhaled loxapine is given as a single acute dose, which limits exposure, but it can cause bronchospasm and sedation.
What this interaction means in plain words
Lithium and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine blockade with possible lithium-related neurotoxicity; the mechanism is not fully established.
What to do
Monitor for rigidity, fever, confusion, tremor and autonomic instability after dosing. Check lithium levels if neurological symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Loxapine inhaled?
MediHelp rates the interaction as moderate. Lithium and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lithium combined with antipsychotics has been associated with neurotoxicity, extrapyramidal effects and, rarely, neuroleptic malignant syndrome. Inhaled loxapine is given as a single acute dose, which limits exposure, but it can cause bronchospasm and sedation.
How serious is the interaction between Lithium and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rigidity, fever, confusion, tremor and autonomic instability after dosing. Check lithium levels if neurological symptoms appear.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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