Drug interactions
Lithium + Lsd
Severity: Major
Lithium and Lsd: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium has been associated with severe adverse reactions in people who use LSD, including seizures and prolonged or intensified psychedelic effects. Both act on serotonergic systems. The evidence comes from case reports and surveys.
What this interaction means in plain words
Lithium and Lsd can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Probable pharmacodynamic interaction involving serotonergic pathways; the exact mechanism is not established.
What to do
Advise patients taking lithium to avoid LSD. Seek emergency care for seizures, severe agitation or hyperthermia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Lsd?
MediHelp rates the interaction as major. Lithium and Lsd can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lithium has been associated with severe adverse reactions in people who use LSD, including seizures and prolonged or intensified psychedelic effects. Both act on serotonergic systems. The evidence comes from case reports and surveys.
How serious is the interaction between Lithium and Lsd?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients taking lithium to avoid LSD. Seek emergency care for seizures, severe agitation or hyperthermia.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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