Drug interactions
Lithium + Molindone
Severity: Moderate
Lithium and Molindone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium with antipsychotics has been associated with neurotoxicity, extrapyramidal symptoms and rarely neuroleptic malignant syndrome. The combination is used in practice but needs clinical vigilance.
What this interaction means in plain words
Lithium and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central dopamine blockade with possible lithium-related neurotoxicity; the mechanism is not fully established.
What to do
Monitor for rigidity, fever, tremor, confusion and autonomic instability. Check serum lithium and use the lowest effective doses of both.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Molindone?
MediHelp rates the interaction as moderate. Lithium and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lithium with antipsychotics has been associated with neurotoxicity, extrapyramidal symptoms and rarely neuroleptic malignant syndrome. The combination is used in practice but needs clinical vigilance.
How serious is the interaction between Lithium and Molindone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rigidity, fever, tremor, confusion and autonomic instability. Check serum lithium and use the lowest effective doses of both.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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