Drug interactions
Lithium + Rapacuronium
Severity: Minor
Lithium and Rapacuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium may prolong the neuromuscular blockade produced by nondepolarizing agents. Rapacuronium has been withdrawn from the market in most countries.
What this interaction means in plain words
Lithium and Rapacuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lithium may potentiate neuromuscular blockade at the neuromuscular junction; mechanism not fully established.
What to do
If a neuromuscular blocker is required in a lithium-treated patient, monitor neuromuscular function with a nerve stimulator and titrate dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Rapacuronium?
MediHelp rates the interaction as minor. Lithium and Rapacuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lithium may prolong the neuromuscular blockade produced by nondepolarizing agents. Rapacuronium has been withdrawn from the market in most countries.
How serious is the interaction between Lithium and Rapacuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If a neuromuscular blocker is required in a lithium-treated patient, monitor neuromuscular function with a nerve stimulator and titrate dosing.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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