Drug interactions
Lithium + Romidepsin
Severity: Moderate
Lithium and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with ECG changes including QT prolongation, and lithium may add to this effect. Together they may increase the likelihood of ventricular arrhythmia, particularly with electrolyte abnormalities.
What this interaction means in plain words
Lithium and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check an ECG at baseline and during treatment, and keep potassium and magnesium within normal range. Monitor lithium levels, particularly if chemotherapy causes vomiting or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Romidepsin?
MediHelp rates the interaction as moderate. Lithium and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin has been associated with ECG changes including QT prolongation, and lithium may add to this effect. Together they may increase the likelihood of ventricular arrhythmia, particularly with electrolyte abnormalities.
How serious is the interaction between Lithium and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG at baseline and during treatment, and keep potassium and magnesium within normal range. Monitor lithium levels, particularly if chemotherapy causes vomiting or dehydration.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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