Drug interactions
Lithium + Tegomil fumarate
Severity: Moderate
Lithium and Tegomil fumarate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fumarate esters such as dimethyl fumarate and related drugs can affect renal function, and lithium is renally cleared with a narrow therapeutic index. Combining them may increase renal adverse effects and could raise lithium levels if kidney function declines.
What this interaction means in plain words
Lithium and Tegomil fumarate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Tegomil fumarate belongs to Miscellaneous.
Why it happens
Additive potential for renal impairment; reduced renal function decreases lithium clearance.
What to do
Monitor renal function and serum lithium concentrations periodically, and adjust the lithium dose if creatinine rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Tegomil fumarate?
MediHelp rates the interaction as moderate. Lithium and Tegomil fumarate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fumarate esters such as dimethyl fumarate and related drugs can affect renal function, and lithium is renally cleared with a narrow therapeutic index. Combining them may increase renal adverse effects and could raise lithium levels if kidney function declines.
How serious is the interaction between Lithium and Tegomil fumarate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and serum lithium concentrations periodically, and adjust the lithium dose if creatinine rises.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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