Drug interactions
Lofepramine + Meclizine
Severity: Moderate
Lofepramine and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is a sedating antihistamine with anticholinergic activity, and lofepramine is a tricyclic antidepressant with anticholinergic and sedative properties. Together they can increase dry mouth, constipation, urinary retention, blurred vision, confusion and drowsiness, especially in older adults.
What this interaction means in plain words
Lofepramine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic and sedative pharmacodynamic effects.
What to do
Monitor for anticholinergic and sedative adverse effects, particularly in elderly patients or those with glaucoma, prostatic hypertrophy or cognitive impairment. Reduce the meclizine dose or choose a non-anticholinergic antiemetic if effects become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclizine
Frequently asked questions
Can I take Lofepramine with Meclizine?
MediHelp rates the interaction as moderate. Lofepramine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is a sedating antihistamine with anticholinergic activity, and lofepramine is a tricyclic antidepressant with anticholinergic and sedative properties. Together they can increase dry mouth, constipation, urinary retention, blurred vision, confusion and drowsiness, especially in older adults.
How serious is the interaction between Lofepramine and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic and sedative adverse effects, particularly in elderly patients or those with glaucoma, prostatic hypertrophy or cognitive impairment. Reduce the meclizine dose or choose a non-anticholinergic antiemetic if effects become troublesome.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
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