Drug interactions
Lofepramine + Salbutamol
Severity: Moderate
Lofepramine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine, a tricyclic, may augment cardiovascular effects of salbutamol such as tachycardia and arrhythmia. The effect is usually modest with standard inhaled doses.
What this interaction means in plain words
Lofepramine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic and cardiac effects via norepinephrine reuptake inhibition by the tricyclic.
What to do
Monitor heart rate, blood pressure, and ECG if high doses are used. Avoid excessive beta-agonist dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Frequently asked questions
Can I take Lofepramine with Salbutamol?
MediHelp rates the interaction as moderate. Lofepramine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine, a tricyclic, may augment cardiovascular effects of salbutamol such as tachycardia and arrhythmia. The effect is usually modest with standard inhaled doses.
How serious is the interaction between Lofepramine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure, and ECG if high doses are used. Avoid excessive beta-agonist dosing.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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