Drug interactions
Lofepramine + Terbutaline
Severity: Moderate
Lofepramine and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists such as terbutaline, leading to tachycardia, palpitations, arrhythmias and blood pressure changes. The effect is unpredictable and is best documented with injected or high-dose sympathomimetics.
What this interaction means in plain words
Lofepramine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics inhibit noradrenaline reuptake and alter adrenergic neuronal handling, which can enhance sympathomimetic cardiovascular responses.
What to do
Monitor heart rate, rhythm and blood pressure when terbutaline is given to a patient on lofepramine, particularly with systemic or high-dose use. Reduce the beta-agonist dose or choose an alternative if cardiac symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Frequently asked questions
Can I take Lofepramine with Terbutaline?
MediHelp rates the interaction as moderate. Lofepramine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists such as terbutaline, leading to tachycardia, palpitations, arrhythmias and blood pressure changes. The effect is unpredictable and is best documented with injected or high-dose sympathomimetics.
How serious is the interaction between Lofepramine and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure when terbutaline is given to a patient on lofepramine, particularly with systemic or high-dose use. Reduce the beta-agonist dose or choose an alternative if cardiac symptoms occur.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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