Drug interactions
Lofepramine + Triprolidine
Severity: Moderate
Lofepramine and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with some sedative and anticholinergic properties. Combined with triprolidine, drowsiness and anticholinergic effects such as dry mouth, constipation and urinary retention may be increased.
What this interaction means in plain words
Lofepramine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedative and anticholinergic (antimuscarinic) effects.
What to do
Monitor for excessive sedation and anticholinergic symptoms, particularly in older patients. Consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Frequently asked questions
Can I take Lofepramine with Triprolidine?
MediHelp rates the interaction as moderate. Lofepramine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with some sedative and anticholinergic properties. Combined with triprolidine, drowsiness and anticholinergic effects such as dry mouth, constipation and urinary retention may be increased.
How serious is the interaction between Lofepramine and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and anticholinergic symptoms, particularly in older patients. Consider a non-sedating antihistamine.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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