Drug interactions
Lonapegsomatropin + Olanzapine
Severity: Minor
Lonapegsomatropin and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP450-mediated clearance of some drugs, and olanzapine is cleared by CYP1A2, so its levels could fall slightly. The data are limited and a clinically important loss of efficacy is not established.
What this interaction means in plain words
Lonapegsomatropin and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonapegsomatropin belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Possible growth hormone-mediated induction of CYP1A2 activity.
What to do
Monitor psychiatric response when growth hormone therapy is started or stopped and adjust olanzapine if efficacy changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Olanzapine?
MediHelp rates the interaction as minor. Lonapegsomatropin and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase CYP450-mediated clearance of some drugs, and olanzapine is cleared by CYP1A2, so its levels could fall slightly. The data are limited and a clinically important loss of efficacy is not established.
How serious is the interaction between Lonapegsomatropin and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response when growth hormone therapy is started or stopped and adjust olanzapine if efficacy changes.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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