Drug interactions
Lonapegsomatropin + Pimozide
Severity: Minor
Lonapegsomatropin and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone can increase cytochrome P450 activity, which might lower concentrations of CYP3A4 substrates such as pimozide. Reduced pimozide exposure could lessen control of tics, although the effect is predicted rather than well documented.
What this interaction means in plain words
Lonapegsomatropin and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonapegsomatropin belongs to Endocrine; Pimozide belongs to Central Nervous System.
Why it happens
Possible induction of CYP-mediated metabolism by growth hormone, which may speed pimozide clearance.
What to do
Watch for loss of tic control when lonapegsomatropin is started or its dose is changed. Adjust pimozide cautiously on clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Pimozide?
MediHelp rates the interaction as minor. Lonapegsomatropin and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone can increase cytochrome P450 activity, which might lower concentrations of CYP3A4 substrates such as pimozide. Reduced pimozide exposure could lessen control of tics, although the effect is predicted rather than well documented.
How serious is the interaction between Lonapegsomatropin and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for loss of tic control when lonapegsomatropin is started or its dose is changed. Adjust pimozide cautiously on clinical response.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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