Drug interactions
Loprazolam + Pimozide
Severity: Moderate
Loprazolam and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and taking them together can intensify drowsiness, slow reaction time and impair coordination. Falls and next-day impairment are of particular concern in older patients.
What this interaction means in plain words
Loprazolam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A receptor potentiation and antipsychotic sedative effects.
What to do
Use the lowest effective loprazolam dose for the shortest time and monitor for oversedation. Advise patients against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Loprazolam with Pimozide?
MediHelp rates the interaction as moderate. Loprazolam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and taking them together can intensify drowsiness, slow reaction time and impair coordination. Falls and next-day impairment are of particular concern in older patients.
How serious is the interaction between Loprazolam and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective loprazolam dose for the shortest time and monitor for oversedation. Advise patients against driving and alcohol.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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