Drug interactions
Lorcaserin + Pimozide
Severity: Moderate
Lorcaserin and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist, and combining it with an antipsychotic may increase the risk of serotonin syndrome or neuroleptic malignant syndrome. The risk is thought to be low, but the reactions can be severe when they occur.
What this interaction means in plain words
Lorcaserin and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity combined with dopamine receptor blockade; the interaction is largely theoretical.
What to do
Monitor for agitation, tremor, hyperreflexia, hyperthermia and rigidity, particularly after dose changes. Stop lorcaserin if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Lorcaserin with Pimozide?
MediHelp rates the interaction as moderate. Lorcaserin and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorcaserin is a serotonin 5-HT2C agonist, and combining it with an antipsychotic may increase the risk of serotonin syndrome or neuroleptic malignant syndrome. The risk is thought to be low, but the reactions can be severe when they occur.
How serious is the interaction between Lorcaserin and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, hyperthermia and rigidity, particularly after dose changes. Stop lorcaserin if serotonin toxicity is suspected.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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