Drug interactions
Lormetazepam + Pimozide
Severity: Moderate
Lormetazepam and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use can lead to additive sedation, with drowsiness, impaired coordination and slowed cognitive function. The effect is most pronounced in the elderly and with alcohol.
What this interaction means in plain words
Lormetazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from benzodiazepine GABA-A potentiation and antipsychotic sedation.
What to do
Use the lowest effective lormetazepam dose and monitor for excessive sedation. Counsel against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Lormetazepam with Pimozide?
MediHelp rates the interaction as moderate. Lormetazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use can lead to additive sedation, with drowsiness, impaired coordination and slowed cognitive function. The effect is most pronounced in the elderly and with alcohol.
How serious is the interaction between Lormetazepam and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lormetazepam dose and monitor for excessive sedation. Counsel against driving and alcohol.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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