Drug interactions
Lormetazepam + Triprolidine
Severity: Moderate
Lormetazepam and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lormetazepam is a benzodiazepine hypnotic and triprolidine is a sedating antihistamine. Concurrent use increases sedation and psychomotor impairment, with a higher risk of falls and next-day drowsiness.
What this interaction means in plain words
Lormetazepam and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and H1 receptor blockade.
What to do
Avoid combining where possible and use a non-sedating antihistamine instead. Counsel patients on driving and monitor older adults for confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Frequently asked questions
Can I take Lormetazepam with Triprolidine?
MediHelp rates the interaction as moderate. Lormetazepam and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lormetazepam is a benzodiazepine hypnotic and triprolidine is a sedating antihistamine. Concurrent use increases sedation and psychomotor impairment, with a higher risk of falls and next-day drowsiness.
How serious is the interaction between Lormetazepam and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and use a non-sedating antihistamine instead. Counsel patients on driving and monitor older adults for confusion.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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